ŷ��Ʒ Feature Channel: Liver Disease

Patients with Alcohol Use Disorder at Risk of Liver Disease May be Less Commonly Referred for Liver Treatment if they are primarily seen for Mental Health Disorders

Research Society on Alcoholism — Sat, 21 Sep 2024 10:00:00 EST

People with alcohol use disorder (AUD) who are at risk of advanced liver disease are less likely to be referred for liver evaluation and care if they present primarily with alcohol-related mental health issues or a mental health diagnosis, according to a study of referral practices in Virginia's largest health system. The findings point to the possibility of widespread missed opportunities for treating three conditions that commonly co-occur: AUD, mental health disorders, and liver disease. Recent years have seen notable increases in the USA in alcohol-related deaths, mental health disorders, and hospital admissions relating to alcohol use and concurrent mental health conditions. AUD is a significant cause of liver disease, and both addiction and co-occurring mental illness can be barriers to successful liver treatment. Integrating AUD treatment, mental health care, and hepatology (liver care) is necessary to improve outcomes, but data suggests this approach is not the norm. For the st

Could Your Phone Detect Hepatic Encephalopathy by Listening to You Read?

Michigan Medicine - University of Michigan — Wed, 18 Sep 2024 13:00:01 EST

Research from the University of Michigan suggests that one day a phone app could be able to detect the development of hepatic encephalopathy in patients just by listening to them speak.

What is Liver Transplant Rejection?

Children's Hospital Los Angeles — Tue, 17 Sep 2024 11:05:47 EST

Receiving a liver transplant means also living with the possibility of rejection. Transplant rejection occurs when the body's immune system attacks the new organ. This risk is highest in the first year after the transplant, but rejection can happen at any time. To prevent this, patients take powerful medications to suppress their immune system and reduce inflammation.

Improved prognostic model incorporates HBV viral load data to accurately predict liver cancer risk

American College of Physicians (ACP) — Mon, 16 Sep 2024 17:00:00 EST

A new risk prediction model, the Revised REACH-B, demonstrated superior accuracy and reliability in predicting hepatocellular carcinoma, or liver cancer, risk compared to a previous model, offering improved risk stratification for patients.

Xylyx Bio awarded $2.45M NIH SBIR grant from NIDDK to facilitate development of effective drugs for fibrotic liver disease

Xylyx Bio, Inc. — Mon, 16 Sep 2024 09:05:44 EST

Award supports the development of a cell-based assay platform to help scientists discover and test drug candidates for liver fibrosis.

Type 2 Diabetes Medication Improves Liver Health in Mice Fed High Fat Diet

American Physiological Society (APS) — Fri, 06 Sep 2024 18:05:05 EST

Macrophage mix helps determine rate and fate of fatty liver disease

Sanford Burnham Prebys — Thu, 22 Aug 2024 15:05:43 EST

Formerly known as nonalcoholic steatohepatitis, metabolic dysfunction-associated steatohepatitis (MASH) is an inflammatory disease characterized by liver scarring or fibrosis that progressively impairs liver function. It is a major risk factor for cirrhosis and liver cancer. And because treatment options are limited, MASH is the second leading cause for liver transplants in the United States after cirrhosis caused by chronic hepatitis C infection. A better understanding of the pathological processes that drive MASH is critical to creating effective treatments. In a new paper published August 19, 2024 in PNAS, a team of scientists from Sanford Burnham Prebys, the University of California San Diego School of Medicine and elsewhere, describe the complex interplay between diseased liver cells and macrophages -- a type of white blood cell whose jobs include killing and removing harmful cells and pathogens and helping to spur normal healing.

Adults with chronic liver disease face more healthcare barriers than those with other diseases

University of California, Los Angeles (UCLA), Health Sciences — Wed, 21 Aug 2024 19:05:03 EST

MD Anderson Research Highlights for August 21, 2024

University of Texas MD Anderson Cancer Center — Wed, 21 Aug 2024 12:00:44 EST

The University of Texas MD Anderson Cancer Center's Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson's world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.

How do GLP-1 weight loss drugs affect the liver?

Michigan Medicine - University of Michigan — Tue, 20 Aug 2024 10:30:10 EST

Drugs such as Ozempic, Rybelsus and Wegovy have made news for their abilities to treat diabetes and encourage weight loss. To give a clearer understanding of the benefits and risks of GLP-1 agonists for patients with liver disease, Robert Fontana, M.D., a Michigan Medicine hepatologist, answered our questions.

Inflammatory Bowel Disease Televisits, Added RSV Risks, and More in the August Issue of AJG

American College of Gastroenterology (ACG) — Mon, 19 Aug 2024 08:05:06 EST

The August issue of AJG includes articles on IBD, including the use of telehealth and added risks for RSV hospitalization, and the updated nomenclature for metabolic dysfunction-associated steatotic liver disease (MASLD).

Can meditation and stretching relieve cramping caused by cirrhosis?

Michigan Medicine - University of Michigan — Thu, 15 Aug 2024 14:30:59 EST

People suffering from cirrhosis may find some symptom relief from two accessible activities: stretching and meditation. A study from the University of Michigan compared the two therapies as a means to relieve nocturnal muscle cramps and found both effective.

"You Can Be Both," A Single Mom's Journey to Becoming a Renowned Telomere Scientist

University of North Carolina School of Medicine — Thu, 15 Aug 2024 14:05:35 EST

Taghreed Mohammed Al-Turki, PhD, a postdoctoral researcher in the UNC Lineberger lab of Jack Griffith, PhD, describes her long, difficult, and rewarding journey of becoming a telomere scientist as a first-time mother at the University of North Carolina School of Medicine.

Removing Bile Acid Receptor in Gut Blocks Intestinal Inflammation

American Physiological Society (APS) — Thu, 15 Aug 2024 08:05:14 EST

Removing a nuclear bile acid receptor that regulates glucose and lipid stability from the intestine blocked gut inflammation in mice, according to researchers at Children's Hospital Los Angeles.

New research explores the urea cycle's strong connection to fatty liver disease

Indiana University — Wed, 14 Aug 2024 08:00:32 EST

An Indiana University School of Medicine physician scientist is making strides in understanding the molecular origins of fatty liver disease, a leading cause of liver failure in the United States.

Study: Transplant Possible After Immunotherapy for Advanced Liver Cancer Patients

Cedars-Sinai — Thu, 08 Aug 2024 15:05:12 EST

Liver transplant is considered the best treatment for liver cancer, but only available for patients with early-stage disease. Now a study led by Cedars-Sinai Cancer investigators has concluded that immunotherapy could make liver transplant an option for patients with later-stage cancer as well.

Rutgers Names Nationally Recognized Clinician-Scientist in Obesity and Nonalcoholic Fatty Liver Disease as New Chair of Medicine

Rutgers University-New Brunswick — Wed, 31 Jul 2024 17:05:19 EST

Jeanne M. Clark, a board-certified internal medicine physician with extensive research experience and a nationally renowned expert in the epidemiology and treatment of obesity, will join Rutgers Robert Wood Johnson Medical School as the Henry Rutgers Professor and chair of the Department of Medicine.

Liver cancer growth tied to tryptophan intake

UT Southwestern Medical Center — Wed, 31 Jul 2024 10:05:55 EST

Researchers at UT Southwestern Medical Center have discovered that a diet free of the amino acid tryptophan can effectively halt the growth of liver cancer in mice. Their findings, published in Nature Communications, offer new insights for dietary-based cancer treatments and highlight the critical role of the tryptophan metabolite indole 3-pyruvate (I3P) in liver tumor development.

Current perspectives on mesenchymal stem cells as a potential therapeutic strategy for non-alcoholic fatty liver disease

World Journal of Stem Cells — Fri, 26 Jul 2024 12:00:23 EST

Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant health challenge, characterized by its widespread prevalence, intricate natural progression and multifaceted pathogenesis. Although NAFLD initially presents as benign fa

Study finds targeting inflammation may not help reduce liver fibrosis in MAFLD

University of California, Los Angeles (UCLA), Health Sciences — Fri, 26 Jul 2024 12:00:00 EST

Researchers at UCLA Health uncovered new information about the role inflammation plays in mitigating liver fibrosis, which is associated with metabolic-associated fatty liver disease (MAFLD), one of the most common diseases in the world affecting up to 40 percent of U.S. adults.

ŷ����Ʒ Feature Channel: Liver Disease