鈥淲e have been suspicious for some time that the neuronal precursor cells (stem cells) in crayfish were coming from the immune system,鈥� Beltz wrote. 鈥淭he paper contains multiple lines of evidence that support this conclusion, in addition to the experiments showing that blood cells transferred from a donor to a recipient animal generate neurons.鈥�
Beltz, , uses the crustacean brain as the model system because the generations of precursor cells are spatially segregated from one another. According to Beltz, this separation is crucial because it allowed the researchers to determine that the first generation precursors do not self-renew. For the Developmental Cell study, the cells of one crayfish were labeled and this animal鈥檚 blood was used for transfusions into another crayfish. They found that the donor blood cells could generate neurons in the recipient.
In many adult organisms, including humans, neurons in some parts of the brain are continually replenished. While this process is critical for ongoing health, dysfunctions in the production of new neurons may also contribute to several neurological diseases, including clinical depression and some neurodegenerative disorders.
Beltz notes, of course, that it is difficult to extrapolate from crayfish to human disease. However, because of existing research suggesting that stem cells harvested from bone marrow also can become neural precursors and generate neurons, she says it is tempting to suggest that the mechanism proposed in crayfish may also be applicable in evolutionarily higher organisms, perhaps even in humans.
Prior studies conducted in both humans and mice and published about a decade ago, showed that bone marrow recipients who had received a transplant from the opposite gender had neurons with the genetic signature of the opposite sex. The implication was that cells from the bone marrow generated those neurons. However, it is currently thought that neuronal stem cells in mammals, including humans, are self-renewing and therefore do not need to be replenished. Thus, these findings have not been interpreted as contributing to a natural physiological mechanism.
鈥淓very experiment we did confirmed the close relationship between the immune system and adult neurogenesis,鈥� Beltz said. 鈥淥ften when one is doing research, experiments can be fussy or give variable results. But for this work, once we started asking the right questions, the experiments worked first time and every time. The consistency and strength of the data are remarkable.鈥�
鈥淥ur findings in crayfish indicate that the immune system is intimately tied to mechanisms of adult neurogenesis, suggesting a much closer relationship between the immune system and nervous system than has been previously appreciated,鈥� said S枚derh盲ll. If further studies demonstrate a similar relationship between the immune system and brain in mammals, these findings would stimulate a new area of research into immune therapies to target neurological diseases.
Journal Reference: Jeanne L. Benton, Rachel Kery, Jingjing Li, Chadanat Noonin, Irene S枚derh盲ll, Barbara S. Beltz. 鈥淐ells from the Immune System Generate Adult-Born Neurons in Crayfish.鈥� Developmental Cell, 2014; 30 (3): 322 DOI: 10.1016/j.devcel.2014.06.016
About Since 1875, Wellesley College has been the preeminent liberal arts college for women. Known for its intellectual rigor and its remarkable track record for the cultivation of women leaders in every arena, Wellesley鈥攐nly 12 miles from Boston鈥攊s home to some 2300 undergraduates from every state and 75 countries.
RSS