New AI model identifies possible therapies from existing medicines for thousands of diseases, including rare ones with no current treatments. The AI tool generates new insights on its own, applies them to conditions it was not trained for, and offers explanations for its predictions.
Three new studies pinpoint challenges and opportunities for closing health disparities for LGBTQ+ people, showing how the convergence of political and social environments, structural inequities, and implicit and explicit bias within the medical system erode LGBTQ+ well-being.
The new approach marks a major step forward in the design of AI tools to support clinical decisions in cancer diagnosis, therapy. The model uses features of a tumor鈥檚 microenvironment to forecast how a patient might respond to therapy and to help inform individualized treatments.
Harvard Medical School virologist Jonathan Abraham has studied EEE virus in detail. In research published in Nature in 2022 and 2024, Abraham and team mapped the structure and behavior of the cell receptors 鈥� the entryways on the surfaces of cells 鈥� that allow EEE virus and similar viruses to infect their hosts and cause mischief.
At a glance: New research explains how herpes simplex virus can develop resistance to antiviral medicines. Study shows that movements in specific parts of a protein that enable viral replication can alter susceptibility to drugs The findings answer long-standing questions about viral drug resistance and can inform new approaches to designing more effective therapies.
Research in mice sheds light on how thyroid hormone alters wiring in the brain. Findings reveal that thyroid hormone syncs up the brain and body to drive exploratory behavior. Researchers say their work could illuminate new treatments for certain psychiatric conditions.
In a marked advance over current AI models, the new approach captures how proteins act not in isolation but in their cellular and tissue environments.
Researchers outline dangers of developing AI-powered autonomous weapons
Highly localized TB strains are less infectious in cosmopolitan cities and more likely to infect people from the geographic area that is the strain鈥檚 natural habitat.
If current guidelines for cholesterol and high blood pressure treatment remain unchanged, a newly unveiled heart risk calculator would render 16 million people ineligible for preventive therapy.
Over the last century, a once-deadly mosquito-borne virus has evolved so that it no longer sickens humans. New research shows that changes in the virus鈥檚 ability to target human cells paralleled the decline in illness and death. The findings offer important lessons in virology that may help guide better preparedness for future outbreaks of other viral diseases.
Cell biologist embraces new tools to study human development on the smallest scale
Harvard Medical School researchers are studying one of the most mysterious 鈥� and most essential 鈥� senses
At a glance: The four scientists developed genetically engineered immune cells to combat several blood cancers. CAR T-cell therapy has redefined the treatment of blood cancers, saving the lives of tens of thousands of people.
Concerns over medical misinformation are not new, but the COVID-19 pandemic magnified long-simmering tensions over two fundamental concepts: Freedom of speech and the federal government鈥檚 responsibility to protect people from what it considers false and dangerous claims.
The World Health Organization鈥檚 governing body is scheduled to meet on May 27 to discuss a critically needed plan for global pandemic preparedness.
Race-based assessments of lung function have historically assumed different levels of 鈥渘ormal鈥� for different patient groups. New analysis shows that removing from lung function estimates would increase the number of Black patients diagnosed with serious disease.Greater estimated disease severity would change a patient鈥檚 diagnosis, disability compensation, eligibility for certain jobs.
Survey reveals nearly three-quarters of U.S. adults support using emerging technology to screen embryos during IVF for risk of developing certain health conditions or traits that arise from more than one gene. Only about one-third of respondents approved of using the technology to predict traits unrelated to disease. Nearly all expressed concerns about potential negative outcomes for individuals or society. Findings underscore need for public education about benefits, limitations, ethical hazards of polygenic risk scores for embryos.
Understanding the human exposome 鈥� a person鈥檚 myriad health exposures over a lifetime 鈥� can reveal unknowns about diseases not explained fully by our DNA. Artificial intelligence will be indispensable in efforts to understand the role of biology and environment in disease and health.
How well a newly minted doctor scores on their medical board exam appears linked to patients鈥� odds of dying or being readmitted to the hospital. Findings offer reassurance that certification exams, which aim to demonstrate the competence of physicians, capture critical knowledge and clinical judgment skills for physicians.
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